I suppose it really depends on the region, hunting pressure, terrain and a few other factors I haven't even thought of. I've hunted all three, and have all three on the wall. I guess I found the blacktail the most difficult, mostly due to the terrain and amount of cover they had at their disposal, on Vancouver Island, BC. I much prefer to hunt mule deer, although I grew up hunting whitetail's in northwestern Ontario (Thunder Bay area). As I remember, they weren't any pushover, either. As I grew up, I remember reading stories about hunting the West's Mule deer, and they really do it for me. And I get to hunt them every year with archery gear, and every 2 - 3 years with a rifle tag in my pocket.